Getting started

    The Basics

    Reactive changes

    Sources of Error

    Practice Quiz 

• The rise in the peripheral blood count is pretty much the same for both bacterial infections and nonspecific necrosis.
• PMNs predominate here.
• PMNs are short lived and their numbers must be renewed directly in the bone marrow.
• Some other classes of inflammatory cells can reproduce at the site of injury (lymphs and macrophages), but not PMNs.
• Depending on the severity of the insult, there are three changes seen consistently:
• Rapid rise in WBC count, primarily PMNs.
• Immature PMNs appear (left shifted differential)
• Reactive changes in the cytoplasm.
• Toxic granualtion
• Dohle bodies.